Explainable Machine Learning for Predicting Global Malaria Incidence From 2000 to 2022 With Climatic and Extreme Weather Conditions Across 78 Endemic Countries: A Retrospective Ecological Study
Background: Climate and extreme weather are increasingly seen as drivers of malaria transmission, but their relative contributions are poorly quantified. This study uses machine learning and explainable AI to identify the key climatic and extreme-weather determinants of malaria and to predict incidence.
Methods: Malaria incidence in 78 endemic countries (2000–2022) was linked with climatic and extreme-weather indicators from WHO, the EM-DAT disaster database and the Global Data Lab. A random forest model was evaluated with R², RMSE and MAE, and SHAP was used to rank predictors.
Results: Incidence declined steadily over the period and stayed highest in Sub-Saharan Africa. Random forest performed best (R² = 0.88, RMSE = 39.21, MAE = 27.33), with gradient boosting close behind. Average annual surface temperature and precipitation were the leading predictors, followed by storm- and flood-affected population measures; climatic variables contributed much more than disaster indicators.
Conclusion: Random forest combined with explainable AI offers an interpretable framework for predicting malaria incidence and supports climate-adaptive public health planning.